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TitleVitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains.
Journal, issue, pagesJ Enzyme Inhib Med Chem, Vol. 39, Page 2372734-2372734, Year 2024
Publish dateOct 19, 2023 (structure data deposition date)
AuthorsWojtys, M.I. / Maksymiuk, W. / Narczyk, M. / Bubic, A. / Asler, I.L. / Krzyzek, P. / Gosciniak, G. / Jagusztyn-Krynicka, E.K. / Bzowska, A.
External linksJ Enzyme Inhib Med Chem / PubMed:39149761
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-8qwa:
Adenylosuccinate Synthetase from H. pylori in complex with PLP and IMP
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-IMP:
INOSINIC ACID

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • helicobacter pylori 26695 (bacteria)
KeywordsLIGASE / purine salvage pathway / complex with inhibitor / AMP precursos synthesis

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