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TitleBactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H.
Journal, issue, pagesFaseb Bioadv, Vol. 6, Page 235-248, Year 2024
Publish dateNov 8, 2022 (structure data deposition date)
AuthorsVeggi, D. / Chesterman, C.C. / Santini, L. / Huang, Y. / Pacchiani, N. / Sierra, J. / Chen, L. / Laliberte, J. / Bianchi, F. / Cozzi, R. ...Veggi, D. / Chesterman, C.C. / Santini, L. / Huang, Y. / Pacchiani, N. / Sierra, J. / Chen, L. / Laliberte, J. / Bianchi, F. / Cozzi, R. / Frigimelica, E. / Maione, D. / Finco, O. / Bottomley, M.J.
External linksFaseb Bioadv / PubMed:39114449
MethodsX-ray diffraction
Resolution2.41 Å
Structure data

PDB-8bk2:
X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-IMD:
IMIDAZOLE

ChemComp-SO4:
SULFATE ION

ChemComp-P33:
3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL / precipitant*YM

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • neisseria meningitidis serogroup b (bacteria)
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Meningococcus / Antigen / Human Monoclonal / fHbp / Bactericidal / Factor H displacement / Vaccine.

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