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Structure paper

TitleDiscovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 13534-13549, Year 2024
Publish dateOct 27, 2023 (structure data deposition date)
AuthorsMa, C. / Kang, D. / Gao, P. / Zhang, W. / Wu, X. / Xu, Z. / Han, H. / Zhang, L. / Cai, Y. / Wang, Y. / Long, W.
External linksJ. Med. Chem. / PubMed:39110625
MethodsX-ray diffraction
Resolution2.02 Å
Structure data

PDB-8wx7:
Crystal structure of SHP2 in complex with JAB-3186
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL


ChemComp, No image

ChemComp-XD8:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphatase cancer

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