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Structure paper

TitleNatural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5.
Journal, issue, pagesCell, Vol. 187, Page 4981-4995.e14, Year 2024
Publish dateJul 21, 2023 (structure data deposition date)
AuthorsWang, L.T. / Cooper, A.J.R. / Farrell, B. / Miura, K. / Diouf, A. / Muller-Sienerth, N. / Crosnier, C. / Purser, L. / Kirtley, P.J. / Maciuszek, M. ...Wang, L.T. / Cooper, A.J.R. / Farrell, B. / Miura, K. / Diouf, A. / Muller-Sienerth, N. / Crosnier, C. / Purser, L. / Kirtley, P.J. / Maciuszek, M. / Barrett, J.R. / McHugh, K. / Ogwang, R. / Tucker, C. / Li, S. / Doumbo, S. / Doumtabe, D. / Pyo, C.W. / Skinner, J. / Nielsen, C.M. / Silk, S.E. / Kayentao, K. / Ongoiba, A. / Zhao, M. / Nguyen, D.C. / Lee, F.E. / Minassian, A.M. / Geraghty, D.E. / Traore, B. / Seder, R.A. / Wilder, B.K. / Crompton, P.D. / Wright, G.J. / Long, C.A. / Draper, S.J. / Higgins, M.K. / Tan, J.
External linksCell / PubMed:39059381
MethodsX-ray diffraction
Resolution1.945 - 3.2 Å
Structure data

PDB-8pwu:
PfRH5 bound to monoclonal antibody MAD10-255
Method: X-RAY DIFFRACTION / Resolution: 3.148 Å

PDB-8pwv:
PfRH5 bound to monoclonal antibody MAD8-502
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-8pww:
PfRH5 bound to monoclonal antibody MAD8-151
Method: X-RAY DIFFRACTION / Resolution: 1.945 Å

PDB-8pwx:
PfRH5 bound to monoclonal antibody R5.008
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-8q5d:
PfRH5 bound to monoclonal antibody MAD10-466
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • plasmodium falciparum 3d7 (eukaryote)
  • homo sapiens (human)
KeywordsCELL CYCLE / Plasmodium falciparum / malaria / monoclonal antibody / growth-inhibition / blood stage / erythrocyte invasion / CELL ADHESION / Plasmodium falciparum; monoclonal antibody; PfRH5; erythrocyte invasion

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