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Structure paper

TitleStructure-based humanization of a therapeutic antibody for multiple myeloma.
Journal, issue, pagesJ. Mol. Med., Vol. 102, Page 1151-1161, Year 2024
Publish dateOct 25, 2023 (structure data deposition date)
AuthorsMarino, S.F. / Daumke, O.
External linksJ. Mol. Med. / PubMed:39052065
MethodsX-ray diffraction
Resolution2.72 - 3.1 Å
Structure data

PDB-8qy9:
J22.9-H, fully humanized Fab Fragment based on chimeric J22.9-xi IgG against BCMA
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-8qya:
J22.9-FNY, fully humanized, CDR optimized Fab Fragment based on chimeric J22.9-xi IgG against BCMA; with VH CDR2 glycosylation
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-8qyb:
J22.9-ISY, fully humanized and CDR optimized Fab Fragment based on chimeric J22.9-xi IgG against BCMA
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

Chemicals

ChemComp-CU:
COPPER (II) ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab fragment / humanized / BCMA binding / CDR derivatized

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