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Structure paper

TitleHumanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework.
Journal, issue, pagesAntibodies, Vol. 13, Year 2024
Publish dateMar 27, 2024 (structure data deposition date)
AuthorsKassardjian, A. / Ivanochko, D. / Barber, B. / Jetha, A. / Julien, J.P.
External linksAntibodies / PubMed:39051333
MethodsX-ray diffraction
Resolution1.73 - 3.08 Å
Structure data

PDB-9b74:
Crystal structure of humanized 44H10 Fab Version 14
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

PDB-9b75:
Crystal structure of humanized 44H10 Fab Version 17
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-9b76:
Crystal structure of humanized 44H10 Fab Version 21
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-9b7b:
Crystal structure of humanized 44H10 Fab Version 22 in complex with HLA-DR (HLA-DRA*01:01/HLA-DRB1*04:01)
Method: X-RAY DIFFRACTION / Resolution: 3.08 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / Humanized / MHC class II

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