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TitleDesign, synthesis, and evaluation of antitumor activity of 2-arylmethoxy-4-(2-fluoromethyl-biphenyl-3-ylmethoxy) benzylamine derivatives as PD-1/PD-l1 inhibitors.
Journal, issue, pagesEur. J. Med. Chem., Vol. 276, Page 116683-116683, Year 2024
Publish dateMar 25, 2024 (structure data deposition date)
AuthorsZhang, F. / Zhang, H. / Zhou, S. / Plewka, J. / Wang, M. / Sun, S. / Wu, C. / Yu, Q. / Zhu, M. / Awadasseid, A. ...Zhang, F. / Zhang, H. / Zhou, S. / Plewka, J. / Wang, M. / Sun, S. / Wu, C. / Yu, Q. / Zhu, M. / Awadasseid, A. / Wu, Y. / Magiera-Mularz, K. / Zhang, W.
External linksEur. J. Med. Chem. / PubMed:39032403
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-9ery:
Co-crystal strucutre of PD-L1 with low molecular weight inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals


ChemComp, No image

ChemComp-VVH:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / PD-L1 / inhibitor / immunotheraphy

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