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TitleBitopic Ligands Support the Presence of a Metastable Binding Site at the beta 2 Adrenergic Receptor.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 11053-11068, Year 2024
Publish dateFeb 19, 2024 (structure data deposition date)
AuthorsGaiser, B.I. / Danielsen, M. / Xu, X. / Ropke Jorgensen, K. / Fronik, P. / Marcher-Rorsted, E. / Wrobel, T.M. / Liu, X. / Mosolff Mathiesen, J. / Sejer Pedersen, D.
External linksJ. Med. Chem. / PubMed:38952152
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-8w1v:
The beta2 adrenergic receptor bound to a bitopic ligand
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

PDB-1ae2:
MUTANT L32R OF GENE V PROTEIN (SINGLE-STRANDED DNA BINDING PROTEIN)

ChemComp-AV0:
Lauryl Maltose Neopentyl Glycol

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / signal transduction / bitopic ligand / SIGNALING PROTEIN / GPCR

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