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TitleIdentification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 107502-107502, Year 2024
Publish dateDec 10, 2023 (structure data deposition date)
AuthorsGallant, J.P. / Hicks, D. / Shi, K. / Moeller, N.H. / Hoppe, B. / Lake, E.W. / Baehr, C. / Pravetoni, M. / Aihara, H. / LeBeau, A.M.
External linksJ. Biol. Chem. / PubMed:38945452
MethodsX-ray diffraction
Resolution1.55 - 1.85 Å
Structure data

PDB-8v9w:
X-ray crystal structure of JGFN4 complexed with fentanyl
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-8v9x:
X-ray crystal structure of JGFN4 complex with fentanyl
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-8v9y:
X-ray crystal structure of nanobody JGFN4
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-8v9z:
X-ray crystal structure of JGFN4 N76D complexed with fentanyl in monomer form
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-8va0:
X-ray crystal structure of JGFN4 N76D complexed with fentanyl in dimer form
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-7V7:
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide / medication*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-PGE:
TRIETHYLENE GLYCOL

Source
  • camelidae (mammal)
KeywordsANTITOXIN

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