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TitleAZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults.
Journal, issue, pagesSci Transl Med, Vol. 16, Page eado2817-eado2817, Year 2024
Publish dateMay 12, 2023 (structure data deposition date)
AuthorsCai, Y. / Diallo, S. / Rosenthal, K. / Ren, K. / Flores, D.J. / Dippel, A. / Oganesyan, V. / van Dyk, N. / Chen, X. / Cantu, E. ...Cai, Y. / Diallo, S. / Rosenthal, K. / Ren, K. / Flores, D.J. / Dippel, A. / Oganesyan, V. / van Dyk, N. / Chen, X. / Cantu, E. / Choudhary, R. / Sulikowski, M. / Adissu, H. / Chawla, B. / Kar, S. / Liu, C. / Dijokaite-Guraliuc, A. / Mongkolsapaya, J. / Rajan, S. / Loo, Y.M. / Beavon, R. / Webber, C. / Chang, L.J. / Thomas, S. / Clegg, L. / Zhang, H. / Screaton, G.R. / Philbin, N. / Harre, M. / Selim, A. / Martinez-Alier, N. / Uriel, A. / Cohen, T.S. / Perez, J.L. / Esser, M.T. / Blair, W. / Francica, J.R.
External linksSci Transl Med / PubMed:38924429
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-8suo:
BA.2/AZD1061/AZD3152 structure analysis
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / monoclonal antibody / broadly neutralizing / ACE-2 blocking / RBD binding / VIRAL PROTEIN-IMMUNE SYSTEM complex

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