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TitleDiscovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 12485-12520, Year 2024
Publish dateApr 18, 2024 (structure data deposition date)
AuthorsZhu, W. / Liu, C. / Xi, K. / Li, A. / Shen, L.A. / Li, Y. / Jia, M. / He, Y. / Chen, G. / Chen, Y. ...Zhu, W. / Liu, C. / Xi, K. / Li, A. / Shen, L.A. / Li, Y. / Jia, M. / He, Y. / Chen, G. / Chen, Y. / Chen, K. / Sun, F. / Zhang, D. / Duan, C. / Wang, H. / Wang, D. / Zhao, Y. / Meng, X. / Zhu, D.
External linksJ. Med. Chem. / PubMed:38912577
MethodsX-ray diffraction
Resolution2.5 - 2.8 Å
Structure data

PDB-8z5j:
Beta-catenin Crystal Structure
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-8z61:
Human beta-catenin crystal structure
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / beta-catenin / BCL9

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