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TitleMono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens.
Journal, issue, pagesJ. Mol. Biol., Vol. 436, Page 168667-168667, Year 2024
Publish dateMar 12, 2024 (structure data deposition date)
AuthorsLagoutte, P. / Bourhis, J.M. / Mariano, N. / Gueguen-Chaignon, V. / Vandroux, D. / Moali, C. / Vadon-Le Goff, S.
External linksJ. Mol. Biol. / PubMed:38901640
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-9en2:
Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsCELL ADHESION / COLLAGEN / STRUCTURAL PROTEIN / EXTRACELLULAR MATRIX / FIBROSIS / NANOBODIES

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