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-Structure paper
| Title | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 15, Page 864-872, Year 2024 |
| Publish date | Jan 31, 2024 (structure data deposition date) |
 Authors | Liang, J. / Lambrecht, M.J. / Arenzana, T.L. / Aubert-Nicol, S. / Bao, L. / Broccatelli, F. / Cai, J. / Eidenschenk, C. / Everett, C. / Garner, T. ...Liang, J. / Lambrecht, M.J. / Arenzana, T.L. / Aubert-Nicol, S. / Bao, L. / Broccatelli, F. / Cai, J. / Eidenschenk, C. / Everett, C. / Garner, T. / Gruber, F. / Haghshenas, P. / Huestis, M.P. / Hsu, P.L. / Kou, P. / Jakalian, A. / Larouche-Gauthier, R. / Leclerc, J.P. / Leung, D.H. / Martin, A. / Murray, J. / Prangley, M. / Rutz, S. / Kakiuchi-Kiyota, S. / Satz, A.L. / Skelton, N.J. / Steffek, M. / Stoffler, D. / Sudhamsu, J. / Tan, S. / Wang, J. / Wang, S. / Wang, Q. / Wendorff, T.J. / Wichert, M. / Yadav, A. / Yu, C. / Wang, X. |
 External links | Acs Med. Chem. Lett. / PubMed:38894924 |
| Methods | X-ray diffraction |
| Resolution | 1.76 - 2.4 Å |
| Structure data |  PDB-8vw4:  PDB-8vw5: |
| Chemicals |  ChemComp-MG:  PDB-1aeg:  ChemComp-GOL:  ChemComp-PEG:  ChemComp-HOH:  ChemComp-CA:  PDB-1ad4: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Ubiquitin ligase / E3 / inhibitor / small molecule / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)