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Structure paper

TitleA novel inhalable nanobody targeting IL-4R alpha for the treatment of asthma.
Journal, issue, pagesJ. Allergy Clin. Immunol., Vol. 154, Page 1008-1021, Year 2024
Publish dateJul 20, 2023 (structure data deposition date)
AuthorsZhu, M. / Ma, L. / Zhong, P. / Huang, J. / Gai, J. / Li, G. / Li, Y. / Qiao, P. / Gu, H. / Li, X. ...Zhu, M. / Ma, L. / Zhong, P. / Huang, J. / Gai, J. / Li, G. / Li, Y. / Qiao, P. / Gu, H. / Li, X. / Yin, Y. / Zhang, L. / Deng, Z. / Sun, B. / Chen, Z. / Ding, Y. / Wan, Y.
External linksJ. Allergy Clin. Immunol. / PubMed:38871183
MethodsX-ray diffraction
Resolution2.59 Å
Structure data

PDB-8k4q:
Crystal structure of nanobody HuNb103 bound to human interleukin-4 receptor subunit alpha
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • camelus dromedarius (Arabian camel)
KeywordsCYTOKINE / antibody / complex / IL-4R / IL-4 / IL-13

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