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TitleStructural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan.
Journal, issue, pagesJ. Inorg. Biochem., Vol. 258, Page 112622-112622, Year 2024
Publish dateFeb 2, 2024 (structure data deposition date)
AuthorsParikh, S.J. / Edara, S. / Deodhar, S. / Singh, A.K. / Maekawa, K. / Zhang, Q. / Glass, K.C. / Shah, M.B.
External linksJ. Inorg. Biochem. / PubMed:38852293
MethodsX-ray diffraction
Resolution2.53 - 3.05 Å
Structure data

PDB-8vx0:
CRYSTAL STRUCTURE OF CYP2C9*14 IN COMPLEX WITH LOSARTAN
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

PDB-8vz7:
Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

Chemicals

ChemComp-LSN:
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol

ChemComp-K:
Unknown entry

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-FRU:
beta-D-fructofuranose

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Cytochrome P450 2C9 / Cytochrome P450 2C9*27 genetic variant

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