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-Structure paper
Title | Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA . |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 9759-9771, Year 2024 |
Publish date | Sep 18, 2023 (structure data deposition date) |
![]() | Hicken, E.J. / Brown, K. / Dwulet, N.C. / Gaudino, J.J. / Hansen, E.P. / Hartley, D.P. / Kowalski, J.P. / Laird, E.R. / Lazzara, N.C. / Li, B. ...Hicken, E.J. / Brown, K. / Dwulet, N.C. / Gaudino, J.J. / Hansen, E.P. / Hartley, D.P. / Kowalski, J.P. / Laird, E.R. / Lazzara, N.C. / Li, B. / Mou, T.C. / Mutryn, M.F. / Oko, L. / Pajk, S. / Pipal, R.W. / Rosen, R.Z. / Shelp, R. / Singh, A. / Wang, J. / Wise, C.E. / Wong, C. / Wong, J.Y. |
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Methods | X-ray diffraction |
Resolution | 1.69 Å |
Structure data | ![]() PDB-8u8x: |
Chemicals | ![]()
ChemComp-W9N: ![]() ChemComp-PEG: ![]() ChemComp-CL: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / TRANSFERASE/INHIBITOR / PROTO-ONCOGENE C-ERBB-2 / TYROSINE KINASE-TYPE CELL SURFACE / TRANSFERASE-INHIBITOR complex |