Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Journal, issue, pages	J. Med. Chem., Vol. 67, Page 8988-9027, Year 2024
Publish date	Jul 3, 2023 (structure data deposition date)
Authors	Thomson, C. / Barton, P. / Braybrooke, E. / Colclough, N. / Dong, Z. / Evans, L. / Floc'h, N. / Guerot, C. / Hargreaves, D. / Khurana, P. ...Thomson, C. / Barton, P. / Braybrooke, E. / Colclough, N. / Dong, Z. / Evans, L. / Floc'h, N. / Guerot, C. / Hargreaves, D. / Khurana, P. / Li, S. / Li, X. / Lister, A. / McCoull, W. / McWilliams, L. / Orme, J.P. / Packer, M.J. / Swaih, A.M. / Ward, R.A. / Winlow, P. / Ye, Y.
External links	J. Med. Chem. / PubMed:38770784
Methods	X-ray diffraction
Resolution	1.621 - 2.523 Å
Structure data	PDB-8pnz: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR Method: X-RAY DIFFRACTION / Resolution: 2.51 Å PDB-8po0: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG Method: X-RAY DIFFRACTION / Resolution: 2.523 Å PDB-8po1: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 22 bound to EGFRinsNPG [V948R] Method: X-RAY DIFFRACTION / Resolution: 2.11 Å PDB-8po2: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R] Method: X-RAY DIFFRACTION / Resolution: 2.28 Å PDB-8po3: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R] Method: X-RAY DIFFRACTION / Resolution: 2.13 Å PDB-8po4: Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R] Method: X-RAY DIFFRACTION / Resolution: 1.621 Å
Chemicals	ChemComp, No image ChemComp-2I0: Unknown entry ChemComp-HOH: WATER ChemComp, No image ChemComp-2I6: Unknown entry ChemComp, No image ChemComp-2EI: Unknown entry ChemComp-IOD: IODIDE ION ChemComp, No image ChemComp-26X: Unknown entry ChemComp, No image ChemComp-2II: Unknown entry ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying moleculeYM ChemComp-MG*: Unknown entry
Source	homo sapiens (human)
Keywords	SIGNALING PROTEIN / EGFR / Exon 20 insertion / non-small cell lung cancer / oncology