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TitleStructural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin.
Journal, issue, pagesBiochemistry, Vol. 63, Page 1241-1245, Year 2024
Publish dateFeb 28, 2024 (structure data deposition date)
AuthorsNakahara, M. / Watanabe, S. / Sato, M. / Okumura, H. / Kawatani, M. / Osada, H. / Hara, K. / Hashimoto, H. / Watanabe, K.
External linksBiochemistry / PubMed:38724483
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-8yhr:
DHODH in complex with furocoumavirin
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-ORO:
OROTIC ACID

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

PDB-1lyu:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / dihydroorotate dehydrogenase / dhodh / inhibitor

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