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Title | SARS-CoV-2 M pro responds to oxidation by forming disulfide and NOS/SONOS bonds. |
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Journal, issue, pages | Nat Commun, Vol. 15, Page 3827-3827, Year 2024 |
Publish date | Oct 8, 2021 (structure data deposition date) |
Authors | Reinke, P.Y.A. / Schubert, R. / Oberthur, D. / Galchenkova, M. / Rahmani Mashhour, A. / Gunther, S. / Chretien, A. / Round, A. / Seychell, B.C. / Norton-Baker, B. ...Reinke, P.Y.A. / Schubert, R. / Oberthur, D. / Galchenkova, M. / Rahmani Mashhour, A. / Gunther, S. / Chretien, A. / Round, A. / Seychell, B.C. / Norton-Baker, B. / Kim, C. / Schmidt, C. / Koua, F.H.M. / Tolstikova, A. / Ewert, W. / Pena Murillo, G.E. / Mills, G. / Kirkwood, H. / Brognaro, H. / Han, H. / Koliyadu, J. / Schulz, J. / Bielecki, J. / Lieske, J. / Maracke, J. / Knoska, J. / Lorenzen, K. / Brings, L. / Sikorski, M. / Kloos, M. / Vakili, M. / Vagovic, P. / Middendorf, P. / de Wijn, R. / Bean, R. / Letrun, R. / Han, S. / Falke, S. / Geng, T. / Sato, T. / Srinivasan, V. / Kim, Y. / Yefanov, O.M. / Gelisio, L. / Beck, T. / Dore, A.S. / Mancuso, A.P. / Betzel, C. / Bajt, S. / Redecke, L. / Chapman, H.N. / Meents, A. / Turk, D. / Hinrichs, W. / Lane, T.J. |
External links | Nat Commun / PubMed:38714735 |
Methods | X-ray diffraction |
Resolution | 1.65 - 2.25 Å |
Structure data | PDB-7pxz: PDB-7pzq: PDB-7z2k: |
Chemicals | ChemComp-CL: ChemComp-HOH: ChemComp-DMS: ChemComp-MLI: |
Source |
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Keywords | VIRAL PROTEIN / 3C-like protease / Main-Protease / Viral replication / Polyprotein maturation / HYDROLASE / main protease / MPro / cystein protease / drug development / drug target / peptide-like inhibitor / SARS-CoV-2 / COVID-19 |