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-Structure paper
Title | Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 8383-8395, Year 2024 |
Publish date | Aug 21, 2023 (structure data deposition date) |
Authors | Pfaffenbach, M. / Bolduc, P.N. / Xin, Z. / Gao, F. / Evans, R. / Fang, T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. / Mathieu, S. ...Pfaffenbach, M. / Bolduc, P.N. / Xin, Z. / Gao, F. / Evans, R. / Fang, T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. / Mathieu, S. / Metrick, C. / Vera Rebollar, J.A. / Gu, R.F. / Mccarl, C.A. / Silbereis, J. / Peterson, E.A. |
External links | J. Med. Chem. / PubMed:38695469 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-8tx0: |
Chemicals |
ChemComp-VEU: ChemComp-EDO: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex |