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Structure paper

TitleGroup 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Journal, issue, pagesNat Commun, Vol. 15, Page 3483-3483, Year 2024
Publish dateJan 18, 2023 (structure data deposition date)
AuthorsShendy, N.A.M. / Bikowitz, M. / Sigua, L.H. / Zhang, Y. / Mercier, A. / Khashana, Y. / Nance, S. / Liu, Q. / Delahunty, I.M. / Robinson, S. ...Shendy, N.A.M. / Bikowitz, M. / Sigua, L.H. / Zhang, Y. / Mercier, A. / Khashana, Y. / Nance, S. / Liu, Q. / Delahunty, I.M. / Robinson, S. / Goel, V. / Rees, M.G. / Ronan, M.A. / Wang, T. / Kocak, M. / Roth, J.A. / Wang, Y. / Freeman, B.B. / Orr, B.A. / Abraham, B.J. / Roussel, M.F. / Schonbrunn, E. / Qi, J. / Durbin, A.D.
External linksNat Commun / PubMed:38664416
MethodsX-ray diffraction
Resolution1.53 - 2.1 Å
Structure data

PDB-8fv2:
Bromodomain of CBP liganded with CCS-1477
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-8fvf:
Bromodomain of EP300 liganded with CCS-1477
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-8fvk:
First bromodomain of BRD4 liganded with CCS-1477
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

PDB-8fvs:
Bromodomain of CBP liganded with CCS1477int
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8fxa:
Bromodomain of CBP liganded with iCBP4
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8fxe:
Bromodomain of CBP liganded with iCBP6
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-8fxo:
Bromodomain of CBP liganded with iCBP8
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-8g6t:
Bromodomain of CBP liganded with inhibitor iCBP2
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8ga2:
Bromodomain of CBP liganded with inhibitor iCBP5
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-JHL:
(6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NI:
NICKEL (II) ION

ChemComp-SO4:
SULFATE ION

ChemComp-YBE:
tert-butyl [(1R,4s)-4-{(5M)-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(2S)-6-oxopiperidin-2-yl]-1H-benzimidazol-1-yl}cyclohexyl]carbamate

ChemComp-MG:
Unknown entry


ChemComp, No image

ChemComp-YJY:
Unknown entry


ChemComp, No image

ChemComp-YID:
Unknown entry


ChemComp, No image

ChemComp-YN5:
Unknown entry


ChemComp, No image

ChemComp-YRI:
Unknown entry


ChemComp, No image

ChemComp-YVK:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / bromodomain / small molecule ligand / complex / TRANSCRIPTION / TRANSCRIPTION-INHIBITOR complex / TRANSFERASE / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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