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TitleCrystal structures of human CD40 in complex with monoclonal antibodies dacetuzumab and bleselumab.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 714, Page 149969-149969, Year 2024
Publish dateApr 1, 2024 (structure data deposition date)
AuthorsAsano, R. / Nakakido, M. / Perez, J.F. / Ise, T. / Caaveiro, J.M.M. / Nagata, S. / Tsumoto, K.
External linksBiochem. Biophys. Res. Commun. / PubMed:38657446
MethodsX-ray diffraction
Resolution2.7 - 2.8 Å
Structure data

PDB-8yx1:
CD40 in complex with Bleselumab Fab
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-8yx9:
CD40 in complex with Dacetuzumab Fab
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD40 / Dacetuzumab / Bleselumab / agonist activity / tumor necrosis factor

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