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TitleStructural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 268, Page 131721-131721, Year 2024
Publish dateJan 26, 2024 (structure data deposition date)
AuthorsChen, X. / Ke, H. / Li, W. / Yin, L. / Chen, W. / Chen, T. / Wu, Y. / Qiu, J. / Feng, W.
External linksInt. J. Biol. Macromol. / PubMed:38649079
MethodsX-ray diffraction
Resolution2.68 - 2.87 Å
Structure data

PDB-8y2k:
The crystal structure of QX006N-Fab
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

PDB-8y31:
The crystal structure of the QX006N-Fab/IFNAR1-SD123 complex
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / therapeutic monoclonal antibody / QX006N / IFNAR1 / the QX006N-Fab-IFNAR1-SD123 complex

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