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TitleEmerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Journal, issue, pagesNat Commun, Vol. 15, Page 3284-3284, Year 2024
Publish dateJan 25, 2023 (structure data deposition date)
AuthorsLiu, C. / Das, R. / Dijokaite-Guraliuc, A. / Zhou, D. / Mentzer, A.J. / Supasa, P. / Selvaraj, M. / Duyvesteyn, H.M.E. / Ritter, T.G. / Temperton, N. ...Liu, C. / Das, R. / Dijokaite-Guraliuc, A. / Zhou, D. / Mentzer, A.J. / Supasa, P. / Selvaraj, M. / Duyvesteyn, H.M.E. / Ritter, T.G. / Temperton, N. / Klenerman, P. / Dunachie, S.J. / Paterson, N.G. / Williams, M.A. / Hall, D.R. / Fry, E.E. / Mongkolsapaya, J. / Ren, J. / Stuart, D.I. / Screaton, G.R.
External linksNat Commun / PubMed:38627386
MethodsX-ray diffraction
Resolution2.33 - 3.77 Å
Structure data

PDB-8cbd:
SARS-CoV-2 Delta-RBD complexed with BA.4/5-1 and EY6A Fabs
Method: X-RAY DIFFRACTION / Resolution: 3.52 Å

PDB-8cbe:
SARS-CoV-2 Delta-RBD complexed with BA.4/5-2 and Beta-49 Fabs
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

PDB-8cbf:
SARS-CoV-2 Delta-RBD complexed with Omi-42 and Beta-49 Fabs
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

PDB-8cma:
SARS-CoV-2 Delta-RBD complexed with BA.4/5-35 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.29 Å

PDB-8qzr:
SARS-CoV-2 delta RBD complexed with BA.4/5-9 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.77 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / SARS-CoV-2 / BA.4 mAb / BA.5 mAb / RBD / BA.4/5-1 / BA.4/5-2 / BA.4/5-5 / EY6A / VIRAL PROTEIN/Immune system / Beta-49 / Omi-42 / BA.4/5-35 / BA.4/5 mAbs / BA.4/5-9 mAb

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