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| Title | Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. |
|---|---|
| Journal, issue, pages | Cancer Discov, Vol. 14, Page 994-1017, Year 2024 |
| Publish date | Mar 5, 2024 (structure data deposition date) |
 Authors | Jiang, J. / Jiang, L. / Maldonato, B.J. / Wang, Y. / Holderfield, M. / Aronchik, I. / Winters, I.P. / Salman, Z. / Blaj, C. / Menard, M. ...Jiang, J. / Jiang, L. / Maldonato, B.J. / Wang, Y. / Holderfield, M. / Aronchik, I. / Winters, I.P. / Salman, Z. / Blaj, C. / Menard, M. / Brodbeck, J. / Chen, Z. / Wei, X. / Rosen, M.J. / Gindin, Y. / Lee, B.J. / Evans, J.W. / Chang, S. / Wang, Z. / Seamon, K.J. / Parsons, D. / Cregg, J. / Marquez, A. / Tomlinson, A.C.A. / Yano, J.K. / Knox, J.E. / Quintana, E. / Aguirre, A.J. / Arbour, K.C. / Reed, A. / Gustafson, W.C. / Gill, A.L. / Koltun, E.S. / Wildes, D. / Smith, J.A.M. / Singh, M. |
 External links | Cancer Discov / PubMed:38593348 |
| Methods | X-ray diffraction |
| Resolution | 1.26 - 1.65 Å |
| Structure data |  PDB-9ax6:  PDB-9bfy:  PDB-9bg1: |
| Chemicals |  ChemComp-GNP:  ChemComp-MG:  PDB-1ahb:  ChemComp-HOH:  PDB-1aol:  ChemComp-CL:  PDB-1aoh: |
| Source |
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 Keywords | SIGNALING PROTEIN/INHIBITOR / inhibitor / complex / small GTPase / cancer / tricomplex / SIGNALING PROTEIN-INHIBITOR complex / SIGNALING PROTEIN |
homo sapiens (human)