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TitleStructural Insights Into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 63, Page e202405140-e202405140, Year 2024
Publish dateMar 5, 2024 (structure data deposition date)
AuthorsXu, M. / Xu, H. / Lei, Z. / Xing, B. / Dickschat, J.S. / Yang, D. / Ma, M.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:38584136
MethodsX-ray diffraction
Resolution1.3 - 2.75 Å
Structure data

PDB-8yl9:
Crystal structures of terpene synthases complexed with a substrate mimic
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-8yla:
Crystal structures of terpene synthases complexed with a substrate mimic
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-PPV:
PYROPHOSPHATE

ChemComp-BTM:
N-benzyl-N,N-diethylethanaminium

ChemComp-HOH:
WATER

Source
  • penicillium brasilianum (fungus)
  • neosartorya fischeri (strain atcc 1020 / dsm 3700 / cbs 544.65 / fgsc a1164 / jcm 1740 / nrrl 181 / wb 181) (mold)
KeywordsBIOSYNTHETIC PROTEIN / sesterterpene synthase / terpene cyclase / sesterbrasiliatriene synthase / sesterfisherol synthase

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