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TitlePhotocobilins integrate B12 and bilin photochemistry for enzyme control.
Journal, issue, pagesNat Commun, Vol. 15, Page 2740-2740, Year 2024
Publish dateApr 15, 2023 (structure data deposition date)
AuthorsZhang, S. / Jeffreys, L.N. / Poddar, H. / Yu, Y. / Liu, C. / Patel, K. / Johannissen, L.O. / Zhu, L. / Cliff, M.J. / Yan, C. ...Zhang, S. / Jeffreys, L.N. / Poddar, H. / Yu, Y. / Liu, C. / Patel, K. / Johannissen, L.O. / Zhu, L. / Cliff, M.J. / Yan, C. / Schiro, G. / Weik, M. / Sakuma, M. / Levy, C.W. / Leys, D. / Heyes, D.J. / Scrutton, N.S.
External linksNat Commun / PubMed:38548733
MethodsX-ray diffraction
Resolution1.7 - 2.3 Å
Structure data

PDB-8j2w:
Saccharothrix syringae photocobilins protein, dark state
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8j2x:
Saccharothrix syringae photocobilins protein, light state
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-8j2y:
Acidimicrobiaceae bacterium photocobilins protein, dark state
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-B12:
COBALAMIN

ChemComp-5AD:
5'-DEOXYADENOSINE

ChemComp-BLA:
BILIVERDINE IX ALPHA

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-SCN:
THIOCYANATE ION

Source
  • saccharothrix syringae (bacteria)
  • acidimicrobiaceae bacterium (bacteria)
KeywordsUNKNOWN FUNCTION / cobalamin binding / biliverdin binding / B12-dependent photoreceptor protein / photocobilins

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