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TitleIguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Journal, issue, pagesMol Med, Vol. 30, Page 43-43, Year 2024
Publish dateMay 3, 2023 (structure data deposition date)
AuthorsBloom, J. / Pantouris, G. / He, M. / Aljabari, B. / Mishra, L. / Manjula, R. / Parkins, A. / Lolis, E.J. / Al-Abed, Y.
External linksMol Med / PubMed:38539088
MethodsX-ray diffraction
Resolution1.73 Å
Structure data

PDB-8spn:
Crystal structure of macrophage migration inhibitory factor in complex with T614
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-GOL:
GLYCEROL


ChemComp, No image

ChemComp-7TN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE / Inhibitor / enzyme / complex

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