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Structure paper

TitleStructural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Journal, issue, pagesStructure, Vol. 32, Page 766-779.e7, Year 2024
Publish dateNov 17, 2023 (structure data deposition date)
AuthorsYuan, M. / Peng, L. / Huang, D. / Gavin, A. / Luan, F. / Tran, J. / Feng, Z. / Zhu, X. / Matteson, J. / Wilson, I.A. / Nemazee, D.
External linksStructure / PubMed:38537643
MethodsX-ray diffraction
Resolution1.99 - 3 Å
Structure data

PDB-8v05:
Crystal structure of mouse PLD3
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-8v06:
Crystal structure of mouse PLD3 co-crystallized with 5'Pi-ssDNA for 9 days
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-8v07:
Crystal structure of mouse PLD3 co-crystallized with 5'Pi-ssDNA for 30 days
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-8v08:
Crystal structure of human PLD4 co-crystallized with 5'Pi-ssDNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-CYS:
CYSTEINE

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-ACE:
ACETYL GROUP

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsHYDROLASE / PLD3 / phospholipase / phosphohistidine / nuclease / HYDROLASE/DNA / PLD4 / HYDROLASE-DNA complex

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