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TitleEvolution-inspired engineering of nonribosomal peptide synthetases.
Journal, issue, pagesScience, Vol. 383, Page eadg4320-eadg4320, Year 2024
Publish dateDec 6, 2022 (structure data deposition date)
AuthorsBozhuyuk, K.A.J. / Prave, L. / Kegler, C. / Schenk, L. / Kaiser, S. / Schelhas, C. / Shi, Y.N. / Kuttenlochner, W. / Schreiber, M. / Kandler, J. ...Bozhuyuk, K.A.J. / Prave, L. / Kegler, C. / Schenk, L. / Kaiser, S. / Schelhas, C. / Shi, Y.N. / Kuttenlochner, W. / Schreiber, M. / Kandler, J. / Alanjary, M. / Mohiuddin, T.M. / Groll, M. / Hochberg, G.K.A. / Bode, H.B.
External linksScience / PubMed:38513038
MethodsX-ray diffraction
Resolution3.25 Å
Structure data

PDB-8bw1:
Yeast 20S proteasome in complex with an engineered fellutamide derivative (C14QAL)
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-MYR:
MYRISTIC ACID

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • synthetic construct (others)
KeywordsHYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex / Proteasome / semisynthesis / Inhibitor / Binding Analysis

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