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TitleBiosynthesis of a new skyllamycin in Streptomyces nodosus : a cytochrome P450 forms an epoxide in the cinnamoyl chain.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 22, Page 2835-2843, Year 2024
Publish dateJan 27, 2023 (structure data deposition date)
AuthorsSong, Y. / Amaya, J.A. / Murarka, V.C. / Mendez, H. / Hogan, M. / Muldoon, J. / Evans, P. / Ortin, Y. / Kelly, S.L. / Lamb, D.C. ...Song, Y. / Amaya, J.A. / Murarka, V.C. / Mendez, H. / Hogan, M. / Muldoon, J. / Evans, P. / Ortin, Y. / Kelly, S.L. / Lamb, D.C. / Poulos, T.L. / Caffrey, P.
External linksOrg. Biomol. Chem. / PubMed:38511621
MethodsX-ray diffraction
Resolution1.43 Å
Structure data

PDB-8fz8:
Structure of cytochrome P450sky2
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-OCA:
OCTANOIC ACID (CAPRYLIC ACID)

ChemComp-HOH:
WATER

Source
  • streptomyces nodosus (bacteria)
KeywordsOXIDOREDUCTASE / P450sky2 / epoxidation

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