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TitleA structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins.
Journal, issue, pagesNat Commun, Vol. 15, Page 2485-2485, Year 2024
Publish dateJan 13, 2023 (structure data deposition date)
AuthorsLu, X. / Chandravanshi, M. / Sabbasani, V.R. / Gaikwad, S. / Hughitt, V.K. / Gyabaah-Kessie, N. / Scroggins, B.T. / Das, S. / Myint, W. / Clapp, M.E. ...Lu, X. / Chandravanshi, M. / Sabbasani, V.R. / Gaikwad, S. / Hughitt, V.K. / Gyabaah-Kessie, N. / Scroggins, B.T. / Das, S. / Myint, W. / Clapp, M.E. / Schwieters, C.D. / Dyba, M.A. / Bolhuis, D.L. / Koscielniak, J.W. / Andresson, T. / Emanuele, M.J. / Brown, N.G. / Matsuo, H. / Chari, R. / Citrin, D.E. / Mock, B.A. / Swenson, R.E. / Walters, K.J.
External linksNat Commun / PubMed:38509117
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-8ftq:
Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals


ChemComp, No image

ChemComp-ZTO:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Proteasome / Rpn13 / PROTAC

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