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TitleInhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma.
Journal, issue, pagesMol. Cancer Ther., Vol. 23, Page 949-960, Year 2024
Publish dateNov 29, 2023 (structure data deposition date)
AuthorsPlotnik, J.P. / Richardson, A.E. / Yang, H. / Rojas, E. / Bontcheva, V. / Dowell, C. / Parsons, S. / Wilson, A. / Ravanmehr, V. / Will, C. ...Plotnik, J.P. / Richardson, A.E. / Yang, H. / Rojas, E. / Bontcheva, V. / Dowell, C. / Parsons, S. / Wilson, A. / Ravanmehr, V. / Will, C. / Jung, P. / Zhu, H. / Partha, S.K. / Panchal, S.C. / Mali, R.S. / Kohlhapp, F.J. / McClure, R.A. / Ramathal, C.Y. / George, M.D. / Jhala, M. / Elsen, N.L. / Qiu, W. / Judge, R.A. / Pan, C. / Mastracchio, A. / Henderson, J. / Meulbroek, J.A. / Green, M.R. / Pappano, W.N.
External linksMol. Cancer Ther. / PubMed:38507740
MethodsX-ray diffraction
Resolution2.486 Å
Structure data

PDB-8v4x:
Structure of MALT1 in complex with an allosteric inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.486 Å

Chemicals

PDB-1aab:
NMR STRUCTURE OF RAT HMG1 HMGA FRAGMENT

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/INHIBITOR / Hydrolase / allosteric inhibitor. / HYDROLASE-INHIBITOR complex

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