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TitleCombining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Journal, issue, pagesMol Oncol, Vol. 18, Page 1904-1922, Year 2024
Publish dateFeb 7, 2024 (structure data deposition date)
AuthorsYu, Y. / Bogdan, M. / Noman, M.Z. / Parpal, S. / Bartolini, E. / Van Moer, K. / Kleinendorst, S.C. / Bilgrav Saether, K. / Tresaugues, L. / Silvander, C. ...Yu, Y. / Bogdan, M. / Noman, M.Z. / Parpal, S. / Bartolini, E. / Van Moer, K. / Kleinendorst, S.C. / Bilgrav Saether, K. / Tresaugues, L. / Silvander, C. / Lindstrom, J. / Simeon, J. / Timson, M.J. / Al-Hashimi, H. / Smith, B.D. / Flynn, D.L. / Alexeyenko, A. / Viklund, J. / Andersson, M. / Martinsson, J. / Pokrovskaja Tamm, K. / De Milito, A. / Janji, B.
External linksMol Oncol / PubMed:38506049
MethodsX-ray diffraction
Resolution2.06 Å
Structure data

PDB-8rxr:
Crystal structure of VPS34 in complex with inhibitor SB02024
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

PDB-1h4e:
Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis protein MobA

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-IMD:
IMIDAZOLE

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Inhibitor / Complex / Kinase / Autophagy / Drug Discovery / Signaling

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