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-Structure paper
Title | Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 269, Page 116308-116308, Year 2024 |
Publish date | Sep 15, 2023 (structure data deposition date) |
Authors | Legru, A. / Batista, F.A. / Puszko, A.K. / Bouillon, A. / Maurel, M. / Martinez, M. / Ejjoummany, A. / Ortega Varga, L. / Adler, P. / Mechaly, A. ...Legru, A. / Batista, F.A. / Puszko, A.K. / Bouillon, A. / Maurel, M. / Martinez, M. / Ejjoummany, A. / Ortega Varga, L. / Adler, P. / Mechaly, A. / Hadjadj, M. / Sosnowski, P. / Hopfgartner, G. / Alzari, P.M. / Blondel, A. / Haouz, A. / Barale, J.C. / Hernandez, J.F. |
External links | Eur. J. Med. Chem. / PubMed:38503166 |
Methods | X-ray diffraction |
Resolution | 1.504 - 1.767 Å |
Structure data | PDB-8qke: PDB-8qkg: PDB-8qkj: |
Chemicals | ChemComp-CA: ChemComp-NAG: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Subtilisin / Alpha-ketoamides / SAR |