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Title | Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 4496-4524, Year 2024 |
Publish date | Sep 4, 2022 (structure data deposition date) |
Authors | Imhoff, R.D. / Patel, R. / Safdar, M.H. / Jones, H.B.L. / Pinto-Fernandez, A. / Vendrell, I. / Chen, H. / Muli, C.S. / Krabill, A.D. / Kessler, B.M. ...Imhoff, R.D. / Patel, R. / Safdar, M.H. / Jones, H.B.L. / Pinto-Fernandez, A. / Vendrell, I. / Chen, H. / Muli, C.S. / Krabill, A.D. / Kessler, B.M. / Wendt, M.K. / Das, C. / Flaherty, D.P. |
External links | J. Med. Chem. / PubMed:38488146 |
Methods | X-ray diffraction |
Resolution | 1.799 Å |
Structure data | PDB-8ede: |
Chemicals | ChemComp-WEU: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / UCHL1 / deubiquitylating enzyme / inhibitor / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |