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TitleDiscovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Journal, issue, pagesEur. J. Med. Chem., Vol. 269, Page 116310-116310, Year 2024
Publish dateDec 29, 2023 (structure data deposition date)
AuthorsQiu, X. / Liu, R. / Ling, H. / Zhou, Y. / Ren, X. / Zhou, F. / Zhang, J. / Huang, W. / Wang, Z. / Ding, K.
External linksEur. J. Med. Chem. / PubMed:38479166
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-8xn7:
Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

PDB-1lvt:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase

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