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Structure paper

TitleMolecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.
Journal, issue, pagesSci Adv, Vol. 10, Page eadl2097-eadl2097, Year 2024
Publish dateDec 16, 2022 (structure data deposition date)
AuthorsAbraham, B.G. / Haikarainen, T. / Vuorio, J. / Girych, M. / Virtanen, A.T. / Kurttila, A. / Karathanasis, C. / Heilemann, M. / Sharma, V. / Vattulainen, I. / Silvennoinen, O.
External linksSci Adv / PubMed:38457493
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-8c08:
Crystal structure of JAK2 JH2-K539L
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8c09:
Crystal structure of JAK2 JH2-I559F
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8c0a:
Crystal structure of JAK2 JH2-R683S
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-T7I:
3,5-diphenyl-2-(trifluoromethyl)-1~{H}-pyrazolo[1,5-a]pyrimidin-7-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Janus kinase / pseudokinase / JAK2 / JH2

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