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Structure paper

TitleDesign, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
Journal, issue, pagesEur. J. Med. Chem., Vol. 268, Page 116281-116281, Year 2024
Publish dateDec 26, 2023 (structure data deposition date)
AuthorsChen, X. / Li, H. / Lin, Q. / Dai, S. / Qu, L. / Guo, M. / Zhang, L. / Liao, J. / Wei, H. / Xu, G. ...Chen, X. / Li, H. / Lin, Q. / Dai, S. / Qu, L. / Guo, M. / Zhang, L. / Liao, J. / Wei, H. / Xu, G. / Jiang, L. / Chen, Y.
External linksEur. J. Med. Chem. / PubMed:38432058
MethodsX-ray diffraction
Resolution1.95 - 2.36 Å
Structure data

PDB-8xlo:
FGFR1 kinase domain with a dual-warhead covalent inhibitor CXF-007
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-8xlq:
FGFR4 kinase domain with a dual-warhead covalent inhibitor CXF-007
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

PDB-1lvq:
IC3 of CB1 Bound to G(alpha)i

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / Fibroblast growth factor receptor 1 / TRANSFERASE / TRANSFERASE-INHIBITOR complex / Fibroblast growth factor receptor 4

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