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-Structure paper
Title | Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-beta-thiophenylacrylamides exerts highly selective antifungal activity. |
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Journal, issue, pages | Cell Chem Biol, Vol. 31, Page 760-, Year 2024 |
Publish date | Oct 12, 2023 (structure data deposition date) |
Authors | Puumala, E. / Sychantha, D. / Lach, E. / Reeves, S. / Nabeela, S. / Fogal, M. / Nigam, A. / Johnson, J.W. / Aspuru-Guzik, A. / Shapiro, R.S. ...Puumala, E. / Sychantha, D. / Lach, E. / Reeves, S. / Nabeela, S. / Fogal, M. / Nigam, A. / Johnson, J.W. / Aspuru-Guzik, A. / Shapiro, R.S. / Uppuluri, P. / Kalyaanamoorthy, S. / Magolan, J. / Whitesell, L. / Robbins, N. / Wright, G.D. / Cowen, L.E. |
External links | Cell Chem Biol / PubMed:38402621 |
Methods | X-ray diffraction |
Resolution | 2.73 Å |
Structure data | PDB-8uk6: |
Chemicals | ChemComp-ZN:
ChemComp-WVK: ChemComp-HOH: |
Source |
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Keywords | LIGASE/LIGASE INHIBITOR / Inhibitor / Complex / Allosteric / LIGASE / LIGASE-LIGASE INHIBITOR complex |