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Structure paper

TitleCrystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.
Journal, issue, pagesInt. Immunol., Vol. 36, Page 279-290, Year 2024
Publish dateSep 4, 2023 (structure data deposition date)
AuthorsMori, S. / Nagae, M. / Yamasaki, S.
External linksInt. Immunol. / PubMed:38386511
MethodsX-ray diffraction
Resolution2 - 3.5 Å
Structure data

PDB-8w8t:
Crystal structure of human CLEC12A CRD
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8w9h:
Crystal structure of anti-human CLEC12A antibody 50C1
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8w9j:
Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Pattern Recognition Receptor / Innate immunitiy / C-type lectin receptor / DAMPs / inhibitory antibody / 50C1 / CLEC12A

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