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TitleSynthetic development of a broadly neutralizing antibody against snake venom long-chain neurotoxins
Journal, issue, pagesSci Transl Med, Vol. 16, Page eadk1867-, Year 2024
Publish dateMay 23, 2023 (structure data deposition date)
AuthorsKhalek, I.S. / Senji Laxme, R.R. / Nguyen, Y.T.K. / Khochare, S. / Patel, R.N. / Woehl, J. / Smith, J.M. / Saye-Francisco, K. / Kim, Y. / Misson Mindrebo, L. ...Khalek, I.S. / Senji Laxme, R.R. / Nguyen, Y.T.K. / Khochare, S. / Patel, R.N. / Woehl, J. / Smith, J.M. / Saye-Francisco, K. / Kim, Y. / Misson Mindrebo, L. / Tran, Q. / Kedzior, M. / Bore, E. / Limbo, O. / Verma, M. / Stanfield, R.L. / Menzies, S.K. / Ainsworth, S. / Harrison, R.A. / Burton, D.R. / Sok, D. / Wilson, I.A. / Casewell, N.R. / Sunagar, K. / Jardine, J.G.
External linksSci Transl Med / PubMed:38381847
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-8sxp:
Crystal structure of long neurotoxin from the venom of the king cobra (3FTx-L15) in complex with Fab of broadly neutralizing antibody 95Mat5
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • ophiophagus hannah (king cobra)
KeywordsTOXIN/IMMUNE SYSTEM / snake toxin / antibody / TOXIN / TOXIN-IMMUNE SYSTEM complex

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