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TitleDiverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2315985121-e2315985121, Year 2024
Publish dateJan 8, 2023 (structure data deposition date)
AuthorsZimmermann, C. / Watson, G.M. / Bauersfeld, L. / Berry, R. / Ciblis, B. / Lan, H. / Gerke, C. / Oberhardt, V. / Fuchs, J. / Hofmann, M. ...Zimmermann, C. / Watson, G.M. / Bauersfeld, L. / Berry, R. / Ciblis, B. / Lan, H. / Gerke, C. / Oberhardt, V. / Fuchs, J. / Hofmann, M. / Freund, C. / Rossjohn, J. / Momburg, F. / Hengel, H. / Halenius, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:38377192
MethodsX-ray diffraction
Resolution1.6 - 1.8 Å
Structure data

PDB-8frt:
X-ray crystal structure of the N-terminal region from HCMV US11 binding to HLA-A*02:01
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8fu4:
HCMV US11 peptide binding to HLA-A*02:01
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-CD:
Unknown entry

ChemComp-PGE:
TRIETHYLENE GLYCOL

Source
  • human cytomegalovirus (strain ad169)
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / immunoevasin / molecular mimicry

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