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| Title | The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2. |
|---|---|
| Journal, issue, pages | Febs Lett., Vol. 598, Page 743-757, Year 2024 |
| Publish date | Nov 8, 2023 (structure data deposition date) |
Authors | Bay, Y. / Egeberg Jeppesen, M. / Frydenvang, K. / Francotte, P. / Pirotte, B. / Pickering, D.S. / Kristensen, A.S. / Kastrup, J.S. |
External links | Febs Lett. / PubMed:38369668 |
| Methods | X-ray diffraction |
| Resolution | 1.6 Å |
| Structure data | ![]() PDB-8r32: |
| Chemicals | ![]() ChemComp-GLU: ![]() ChemComp-2J9: ![]() ChemComp-CL: ![]() ChemComp-NA: ![]() ChemComp-HOH: |
| Source |
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Keywords | MEMBRANE PROTEIN / IONOTROPIC GLUTAMATE RECEPTOR / GLUK2 LIGAND-BINDING DOMAIN / POSITIVE ALLOSTERIC MODULATOR / L-glutamate |
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