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Structure paper

TitleAn antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Journal, issue, pagesScience, Vol. 383, Page 721-726, Year 2024
Publish dateSep 28, 2023 (structure data deposition date)
AuthorsWu, K.J.Y. / Tresco, B.I.C. / Ramkissoon, A. / Aleksandrova, E.V. / Syroegin, E.A. / See, D.N.Y. / Liow, P. / Dittemore, G.A. / Yu, M. / Testolin, G. ...Wu, K.J.Y. / Tresco, B.I.C. / Ramkissoon, A. / Aleksandrova, E.V. / Syroegin, E.A. / See, D.N.Y. / Liow, P. / Dittemore, G.A. / Yu, M. / Testolin, G. / Mitcheltree, M.J. / Liu, R.Y. / Svetlov, M.S. / Polikanov, Y.S. / Myers, A.G.
External linksScience / PubMed:38359125
MethodsX-ray diffraction
Resolution2.55 - 2.7 Å
Structure data

PDB-8ud6:
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-8ud7:
Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-8ud8:
Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry


ChemComp, No image

ChemComp-WC9:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus hb8 (bacteria)
  • escherichia phage t4 (virus)
KeywordsRibosome/RNA / Cresomycin / lincosamides / structure-based drug design / antibiotic / resistance / CFR / ERM / methylation / A2058 / A2503 / 23S rRNA / 70S ribosome / inhibition of translation / peptidyl transferase center / nascent peptide exit tunnel / RIBOSOME / Ribosome-RNA complex

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