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TitleNicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 15, Page 205-214, Year 2024
Publish dateJul 28, 2023 (structure data deposition date)
AuthorsGordon-Blake, J. / Ratia, K. / Weidig, V. / Velma, G.R. / Ackerman-Berrier, M. / Penton, C. / Musku, S.R. / Alves, E.T.M. / Driver, T. / Tai, L. / Thatcher, G.R.J.
External linksAcs Med. Chem. Lett. / PubMed:38352833
MethodsX-ray diffraction
Resolution1.79 Å
Structure data

PDB-8tm7:
Human NAMPT in complex with substrate NAM and small molecule activator NP-A3
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NCA:
NICOTINAMIDE / medication*YM


ChemComp, No image

ChemComp-I7Q:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / NAD+ aging enzyme activation

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