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TitleNovel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 2690-2711, Year 2024
Publish dateSep 28, 2023 (structure data deposition date)
AuthorsGimenez, L.E. / Martin, C. / Yu, J. / Hollanders, C. / Hernandez, C.C. / Wu, Y. / Yao, D. / Han, G.W. / Dahir, N.S. / Wu, L. ...Gimenez, L.E. / Martin, C. / Yu, J. / Hollanders, C. / Hernandez, C.C. / Wu, Y. / Yao, D. / Han, G.W. / Dahir, N.S. / Wu, L. / Van der Poorten, O. / Lamouroux, A. / Mannes, M. / Zhao, S. / Tourwe, D. / Stevens, R.C. / Cone, R.D. / Ballet, S.
External linksJ. Med. Chem. / PubMed:38345933
MethodsX-ray diffraction
Resolution2.9 - 3.3 Å
Structure data

PDB-8wky:
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8wkz:
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-OLA:
OLEIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN / Ca++ cofactor / GPCR / PGS fusion / LCP

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