+Search query
-Structure paper
Title | Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 67, Page 2321-2336, Year 2024 |
Publish date | Sep 5, 2023 (structure data deposition date) |
![]() | Robbins, D.W. / Noviski, M.A. / Tan, Y.S. / Konst, Z.A. / Kelly, A. / Auger, P. / Brathaban, N. / Cass, R. / Chan, M.L. / Cherala, G. ...Robbins, D.W. / Noviski, M.A. / Tan, Y.S. / Konst, Z.A. / Kelly, A. / Auger, P. / Brathaban, N. / Cass, R. / Chan, M.L. / Cherala, G. / Clifton, M.C. / Gajewski, S. / Ingallinera, T.G. / Karr, D. / Kato, D. / Ma, J. / McKinnell, J. / McIntosh, J. / Mihalic, J. / Murphy, B. / Panga, J.R. / Peng, G. / Powers, J. / Perez, L. / Rountree, R. / Tenn-McClellan, A. / Sands, A.T. / Weiss, D.R. / Wu, J. / Ye, J. / Guiducci, C. / Hansen, G. / Cohen, F. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.9 - 1.95 Å |
Structure data | ![]() PDB-8u2d: ![]() PDB-8u2e: |
Chemicals | ![]() ChemComp-UQX: ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-UP9: ![]() ChemComp-IOD: |
Source |
|
![]() | TRANSFERASE / protein degradation / leukemia |