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Structure paper

TitleProlinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 63, Page e202319958-e202319958, Year 2024
Publish dateSep 22, 2023 (structure data deposition date)
AuthorsHumboldt, A. / Rami, F. / Topp, F.M. / Arnold, D. / Gohringer, D. / Pallan, P.S. / Egli, M. / Richert, C.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:38300702
MethodsX-ray diffraction
Resolution1.53 - 2 Å
Structure data

PDB-8uax:
Structure of Alanyl-5'-O-adenosine phosphoramidate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8uay:
Structure of Arginyl-5'-O-adenosine phosphoramidate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8uaz:
Structure of Glutamyl-5'-O-adenosine phosphoramidate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-8ub0:
Structure of Histidine-5'-O-adenosine phosphoramidate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8ub1:
Structure of Butyl-5'-O-adenosine phosphoramidate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

PDB-8ub2:
Structure of Adenosine monophosphate/RNase A
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER


ChemComp, No image

ChemComp-WFH:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-WF9:
Unknown entry


ChemComp, No image

ChemComp-WFU:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

PDB-1ba4:
THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES


ChemComp, No image

ChemComp-WFL:
Unknown entry

Source
  • bos taurus (domestic cattle)
KeywordsHYDROLASE / RNase-A / Nucleotide Prodrug / Amino Acidyl Phosphoramidate / Alanyl-5'-AMP / Phosphoramidate Hydrolysis / ProTide / Arginyl-5'-AMP / Glutamyl-5'-AMP / Histidine-5'-AMP / Butyl-5'-AMP / 5'-AMP

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