+Search query
-Structure paper
Title | ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 67, Page 2837-2848, Year 2024 |
Publish date | Jul 22, 2023 (structure data deposition date) |
Authors | Li, Z. / Lu, W. / Beyett, T.S. / Ficarro, S.B. / Jiang, J. / Tse, J. / Kim, A.Y. / Marto, J.A. / Che, J. / Janne, P.A. ...Li, Z. / Lu, W. / Beyett, T.S. / Ficarro, S.B. / Jiang, J. / Tse, J. / Kim, A.Y. / Marto, J.A. / Che, J. / Janne, P.A. / Eck, M.J. / Zhang, T. / Gray, N.S. |
External links | J. Med. Chem. / PubMed:38300264 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-8tjl: |
Chemicals |
ChemComp-HZ6: ChemComp-HOH: |
Source |
|
Keywords | TRANSFERASE/TRANSFERASE inhibitor / EGFR / kinase / covalent inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE inhibitor complex |